A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/32 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2239909
A method and compositions for delivering a compound to the cytoplasm of a cell are disclosed. The compound to be delivered may be an antigenic compound, may be linked to a polycationic affinity handle, or both. In one of the methods disclosed, the B moiety of a toxin, such as the anthrax PA polypeptide, is also provided to enhance delivery of the compound to the cytoplasm of the cell.
Méthode et compositions permettant d'introduire un composé dans le cytoplasme d'une cellule. Le composé à introduire peut être un composé antigène, ou bien être lié à un marqueur d'affinité polycationique, ou les deux. Selon l'une des méthodes révélées, la fraction B d'une toxine, telle que le polypeptide à marqueur d'affinité de l'anthrax, contribue également à renforcer l'introduction du composé dans le cytoplasme de la cellule.
Ballard Jimmy D.
Blanke Steven R.
Collier R. John
Lyszak Ericka L.
Milne Jill C.
Deeth Williams Wall Llp
President And Fellows Of Harvard College
President And Fellows Of Havard College
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