Use of tp modulators for the treatment of cardiovascular...

Details Use of tp modulators for the treatment of cardiovascular... Use of tp modulators for the treatment of cardiovascular...

A - Human Necessities

61

K

A61K 31/4365 (2006.01) A61K 31/34 (2006.01) A61K 31/352 (2006.01) A61K 31/405 (2006.01) A61K 31/421 (2006.01) A61K 31/4406 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) C12Q 1/00 (2006.01) A61K 31/616 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2688317

The present invention provides methods and compositions useful in the treatment or prevention of cardiovascular disorders in individuals for whom therapy with a COX-1 enzyme inhibitor is not feasible due to sensitivity, intolerance, or resistance to the inhibitor. Additionally, the invention provides methods of treating cardiovascular disorders in an individual who is receiving a therapeutically effective dose of a TP modulator and is instructed or advised to avoid and/or not to take aspirin or another COX-1 inhibitor.

La présente invention concerne des procédés et des compositions utiles dans le traitement ou la prévention des troubles cardiovasculaires chez les individus pour lesquels une thérapie basée sur un inhibiteur de l'enzyme COX-1 n'est pas applicable en raison d'une sensibilité, d'une intolérance, ou d'une résistance à l'inhibiteur. De plus, l'invention concerne des procédés pour traiter des troubles cardiovasculaires chez un individu qui reçoit une dose thérapeutiquement efficace d'un modulateur de TP et est informé ou averti du fait qu'il doit éviter et/ou ne doit pas prendre d'aspirine ou autre inhibiteur de COX-1.

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