Use of tranilast and derivatives thereof for the therapy of...

A - Human Necessities – 61 – K

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A61K 31/167 (2006.01) C12N 5/071 (2010.01) C12N 5/0797 (2010.01) A61K 31/196 (2006.01) A61K 31/36 (2006.01) A61K 35/12 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2696582

The present invention relates to the use of tranilast and derivatives thereof for the preparation of a pharmaceutical composition for treating and/or preventing a neuronal condition where there is a need of neuroprotection and neuroregeneration. The invention furthermore relates to the use of tranilast and derivatives thereof for the in vitro differentiation of neuronal stem cells and the use of such pre-treated cells for stem cell therapy von neurological conditions.

La présente invention porte sur l'utilisation de tranilast et de dérivés de celui-ci pour la préparation d'une composition pharmaceutique pour traiter et/ou prévenir un état neuronal lorsqu'une neuroprotection ou une neurorégénération s'avère nécessaire. L'invention porte de plus sur l'utilisation de tranilast et de dérivés de celui-ci pour la différenciation in vitro de cellules souches neuronales et sur l'utilisation de telles cellules prétraitées pour une thérapie à base de cellules souches pour des états neurologiques.

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