G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01)
Patent
CA 2577601
The invention is directed to a method for detecting colorectal adenoma and/or colorectal carcinoma comprising the steps: a) providing an isolated sample material which has been taken from an individual, b) determining the level of transthyretin in said isolated sample material, and c)comparing the determined level of transthyretin with a reference value. The invention is further directed to a method for discriminating between colorectal adenoma and colorectal carcinoma as well as to a method for monitoring the course of colorectal adenoma and/or colorectal carcinoma and/or the treatment of colorectal adenoma and/or colorectal carcinoma. Moreover, the invention is directed to a test system and an array for use in these methods. Furthermore, the invention is directed to the use of transthyretin as a biomarker for a detection of colorectal adenoma and/or colorectal carcinoma in an individual.
L'invention porte sur un procédé de détection d'adénome colorectal et/ou de carcinome colorectal consistant a) à fournir un matériau échantillon isolé prélevé sur un individu, b) à déterminer le niveau de transthyrétine dans ce matériau échantillon isolé, et c) à comparer le niveau déterminé de transthyrétine avec une valeur de référence. Cette invention se rapporte aussi à un procédé de différenciation d'un adénome colorectal d'un carcinome colorectal, ainsi qu'à un procédé de surveillance de l'évolution de l'adénome colorectal et/ou du carcinome colorectal et/ou du traitement de l'adénome colorectal et/ou du carcinome colorectal. De plus, l'invention porte sur un système de test et sur un réseau à utiliser dans ces procédés. Elle concerne également l'utilisation de transthyrétine en tant que biomarqueur afin de détecter un adénome colorectal et/ou un carcinome colorectal chez un individu.
David Kerstin
Juhl Hartmut
Indivumed Gmbh
Piasetzki Nenniger Kvas Llp
LandOfFree
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