Use of treprostinil to treat neuropathic diabetic foot ulcers

A - Human Necessities – 61 – K

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A61K 31/192 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2562614

The present invention describes novel methods for using 9-deoxy-2~, 9-.alpha.- methano-3-oxa-4,5,6-trinor-3,7-(1~,3~-interphenylene)-13,14-dihydro- prostaglandin F1 (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neurophathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

L'invention concerne de nouvelles méthodes pour utiliser de la 9-désoxy-2', 9-.alpha.-méthano-3-oxa-4,5,6-trinor-3,7-(1',3'-interphénylène)-1',3'-dihydro-prostaglandine F¿1? (également connu sous le nom de Tréprostinile) ou ses dérivés, ou un sel pharmaceutiquement acceptable de celle-ci, pour traiter et/ou pour prévenir des ulcères du pied chez des patients présentant une neuropathie diabétique. L'invention concerne également des trousses pour le traitement et/ou pour la prévention d'ulcères du pied. Ces trousses comprennent une quantité efficace de Tréprostinile ou de ses dérivés, ou d'un sel pharmaceutiquement acceptable de celui-ci.

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