Use of triaminobenzene derivatives for treatment of anxiety...

Details Use of triaminobenzene derivatives for treatment of anxiety... Use of triaminobenzene derivatives for treatment of anxiety...

A - Human Necessities

61

K

A61K 31/27 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) A61K 31/18 (2006.01) A61K 31/325 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2431278

This invention provides methods for treating, preventing or inhibiting anxiety, anxiety-related conditions and phobias in a mammal using compounds of the formula (I) wherein: R1 is H, alkyl, alkanoyl or the radical Ar; R2 is H or alkyl; R3 is alkoxy, NH2, alkylamino, dialkylamino, amino substituted by the radical Ar, alkyl, alkenyl, alkynyl, or the radicals Ar or ArO-; R4 is H, alkyl or the radical Ar; R5 is H or alkyl or the radical Ar; or a pharmaceutically acceptable salt or ester form thereof; Ar is an optionally substituted phenyl radical; and n is O or 1, or a pharmaceutically acceptable salt or ester form thereof, with the methods particularly including the use of N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, also known as retigabine.

L'invention concerne des méthodes permettant de traiter, de prévenir ou d'inhiber l'anxiété, les affections et les phobies liées à l'anxiété chez un mammifère à l'aide de composés représentés par la formule (I) dans laquelle: R¿1? représente H, alkyle, alkanoyle ou le radical Ar; R¿2? représente H ou alkyle; R¿3? représente alcoxy, NH¿2?, alkyleamino, dialkyleamino, amino substitué par le radical Ar, alkyle, alcényle, alkynyle, ou les radicaux Ar ou ArO-; R¿4? représente H, alkyle ou le radical Ar; R¿5? représente H ou alkyle ou le radical Ar; Ar représente un radical phényle éventuellement substitué; ou un sel ou ester pharmaceutiquement acceptable de ces composés; et n vaut O ou 1. Ces méthodes consistent notamment à utiliser l'ester éthylique de l'acide N-[2-amino-4-(4-fluorobenzylamino)-phényl]carbamique, également connu sous le nom de rétigabine.

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