Use of tricyclic isoindolinones as anti-viral medicaments as...

A - Human Necessities – 61 – K

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A61K 31/395 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2104963

-36- Summary The invention concerns the use of tricyclic isoindole derivatives of the general formula I (I) Image for the preparation of medicaments with antiviral action, whereby, in formula I,A can be an oxygen or sulphur atom, the imine group =NH or, an N-C1-C5- alkylimino group, Y can be an oxygen or sulphur atom or the NH, C1-C5-alkylamino, C1-C5-alkylcarbonylamino, sulphinyl or sulphonyl group, R signifies a hydrogen atom, an aliphatic radical with 1 - 9 C-atoms possibly substituted by phenyl, a phenyl ring, a carbocyclic ring with 7 - 15 C-atoms or a heterocylic ring system with, in each case, 5 or 6 ring atoms, R1 and R2 signify a hydrogen atom, an aliphatic radical with 1 - 6 C-atoms or C1-C6-alkoxy, C1-C6-alkylmercapto, C1-C6-alkylsulphinyl, C1-C6-alkylsulphonyl, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, sulphonamido, C1-C6-alkoxycarbonyl, carboxyl, halogen, hydroxyl, nitro, cyano, azido, phenyl or benzyloxy, R3 and R4 signify hydrogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C6- alkylmercapto, amino, C1-C6-alkylamino, di-C1-C6- -37- alkylamino, halogen, cyano, hydroxyl, carboxyl or C1-C6-alkoxycarbonyl, as well as of their physio- logically acceptable salts. Furthermore, the subject of the present invention are the optically-active derivatives of the compounds of the formula I.

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