Use of trifunctional bispecific antibodies for the treatment...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2756973

Use of a trifunctional bispecific antibody having the following properties of. a) binding to a T cell; b) binding to EpCAM as tumor-associated antigen on a tumor cell wherein the tumor cell additionally carries the membrane bound glycoprotein CD 133; c) binding by its Fc portion to Fc receptor-positive cells for the preparation of a pharmaceutical composition for the destruction of cancer stem cells carrying the tumor-associated antigen EpCAM and the membrane bound glycoprotein CD 133 in a population of patients suffering from a tumor.

L'invention porte sur l'utilisation d'un anticorps bispécifique trifonctionnel ayant les propriétés suivantes de : a) se lier à un lymphocyte T ; b) se lier à EpCAM en tant qu'antigène associé à une tumeur sur une cellule tumorale, la cellule tumorale portant de plus la glycoprotéine CD133 ; c) se lier par sa partie Fc à des cellules positives pour les récepteurs Fc pour la préparation d'une composition pharmaceutique par la destruction de cellules souches cancéreuses portant l'antigène associé à une tumeur EpCAM et la glycoprotéine liée à la membrane CD133 chez une population de patients souffrant d'une tumeur.

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