A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61K 31/4709 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61P 1/04 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2472293
The present invention relates to the use of quinazolines of general formula (see formula I) wherein A, B, C, D, X, R a, R b, R c and n are defined as in claim 1, or the compounds (1) 4-[(3-chloro-4-fluorophenyl)amino]-6-[(4-dimethylamino-cyclohexyl)amino]- pyrimido[5,4-d]pyrimidine, (2) 4-[(R)-(1-phenylethyl)amino]-6-(4-hydroxyphenyl)-7H-pyrrolo[2,3- d]pyrimidine, (3) 4-{[3-chloro-4-(3-fluoro-4-benzyloxy)-phenyl]amino}-6-(5-{[(2- methanesulphonyl-ethyl)amino]methyl}-furan-2-yl)quinazoline or the antibody Cetuximab C225, Trastuzumab, ABX-EGF, Mab ICR-62 and EGFR- antisense, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, for preparing a pharmaceutical composition for the prevention or treatment of diseases of the airways or lungs.
La présente invention concerne l'utilisation de chinazolines de formule générale (I), dans laquelle A, B, C, D, X, R?a¿, R?b¿, R?c¿ et n sont tels que définis dans la revendication 1, ou des composés (1) 4-[(3-chloro-4-fluorophényl)amino]-6-[(4-diméthylamino-cyclohexyl)amino]-pyrimido[5,4-d]pyrimidin, (2) 4-[(R)-(1-phényléthyl)amino]-6-(4-hydroxyphényl)-7H-pyrrolo[2,3-d]pyrimidin, (3) 4-{[3-chloro-4-(3-fluoro-4-benzyloxy)-phényl]amino}-6-(5-{[(2-méthansulfonyléthyl)amino]méthyl}-furan-2-yl)chinazoline ou des anticorps Cetuximab C225, Trastuzumab, ABX-EGF, Mab ICR-62 et antisens EGFR, de leur tautomères, de leur stéréoisomères et de leurs sels, notamment de leurs sels physiologiquement compatibles présentant des acides ou des bases inorganiques ou organiques, pour produire un médicament servant à prévenir ou à traiter des maladies des voies respiratoires ou des poumons.
Jung Birgit
Pueschner Hubert
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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