Use of urease for inhibiting cancer cell growth

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/50 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2492472

A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject.

La présente invention concerne une composition pharmaceutique et une méthode destiné à être utilisé pour inhiber la croissance de cellules cancéreuses chez un sujet mammifère. Ladite composition comprend une enzyme uréase, à laquelle est associée une entité chimique efficace pour améliorer la libération de l'enzyme sur des cellules cancéreuses, lorsque ladite composition est administrée au sujet. L'invention concerne également une méthode d'amélioration de l'efficacité de composés antitumoraux faiblement basiques, une méthode d'évaluation de la présence, de la taille ou de l'état d'une tumeur solide chez un sujet et une composition de thérapie génique permettant de traiter un cancer chez un sujet.

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