Use of urinastatin-like compounds to prevent premature delivery

Details Use of urinastatin-like compounds to prevent premature delivery Use of urinastatin-like compounds to prevent premature delivery

A - Human Necessities

61

K

A61K 38/57 (2006.01) A61K 38/10 (2006.01) C07K 14/81 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2175328

The present invention provides a method of diagnosing and treating a pregnant female at risk for impending preterm delivery. The method comprises the step of diagnosing imminent preterm delivery by testing with a method that has a sensitivity of at least 80% and a specificity of at least 80%, or by testing for fetal fibronectin in the female's vaginal or cervical secretions. If imminent preterm delivery is indicated by the test, the next step comprises administering to the female a combination of a tocolytic agent, at least one urinastatin-like compound, and at least one antibiotic. Also provided is a pharmaceutical composition of MGMTSRYFYNGTSMA, RAFIQLWAFDAVKGK and an antibiotic.

L'invention concerne un procédé permettant d'établir un diagnostic et de traiter une femme enceinte à risques, pour empêcher un accouchement prématuré. Le procédé consiste à diagnostiquer un accouchement prématuré imminent en procédant à une vérification à l'aide d'un procédé présentant une sensibilité d'au moins 80 % et une spécificité d'au moins 80 % ou en vérifiant l'éventuelle présence de fibronectine foetale dans le vagin ou dans les sécrétions du col de l'utérus. Si les résultats indiquent un risque d'accouchement prématuré, on administre à la femme concernée une combinaison associant un agent tocolytique, au moins un composé de type urinastatine et au moins un antibiotique. L'invention concerne également une composition pharmaceutique constituée de MGMTSRYFYNGTSMA, de RAFIQLWAFDAVKGK et d'un antibiotique.

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