Use of valaciclovir for the manufacture of a medicament for...

A - Human Necessities – 61 – K

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Details

A61K 31/522 (2006.01) A61K 9/20 (2006.01) A61P 31/22 (2006.01)

Patent

CA 2243237

The invention relates to the antiviral drug valaciclovir, the valine ester of 9-[(2-hydroxyethoxy)methyl]guanine (aciclovir), which is known as an effective treatment for genital herpes in a dosage regime of 40 mg, twice to 5 times daily. More specifically, the invention relates to a method for the suppression of recurrent genital herpes in a human host comprising administering to the host from about 200 mg to about 1000 mg valaciclovir or a pharmaceutically acceptable salt thereof once daily for an effective treatment period, as well as to the use of valaciclovir or a pharmaceutically acceptable salt thereof in the preparation of a unit dosage medicament for once daily administration in the suppression of recurrent genital herpes, and to a pharmaceutical composition for administration once daily in the suppression of genital herpes, comprising from 200 mg to 1000 mg valaciclovir or a pharmaceutically acceptable salt thereof, in unit dosage form. Particularly preferred unit dosage forms include tablets and capsules for oral administration. The preferred pharmaceutically acceptable salt of valaciclovir is the hydrochloride salt.

L'invention concerne le médicament antiviral valaciclovir qui est l'ester de valine de -9((2-hydroxyéthoxy)méthyl)guanine (aciclovir), lequel est connu en tant que traitement efficace de l'herpès génital selon un schéma posologique de 40 mg, deux à cinq fois par jour. L'invention concerne plus spécialement un procédé de suppression de l'herpès génital récurrent chez l'homme, consistant à administrer à celui-ci environ 200 à environ 1000 mg de valaciclovir, ou d'un sel de celui-ci acceptable sur le plan pharmacologique, en une seule prise journalière pendant la période utile de traitement. On décrit encore l'utilisation de valaciclovir, ou d'un sel de celui-ci acceptable sur le plan pharmacologique, dans la préparation d'un médicament à dose unitaire destinée à une seule administration journalière dans la suppression de l'herpès génital récurrent, ainsi qu'à une composition pharmaceutique destinée à ladite administration, laquelle composition comprend, sous dose unitaire, 200 à 1000 mg de valaciclovir, ou d'un sel de celui-ci acceptable sur le plan pharmacologique. Des formes de dosage unitaire préférées comprennent des comprimés et gélules destinés à une administration orale. Le sel de valaciclovir préféré et acceptable sur le plan pharmacologique est le sel d'hydrochlorure.

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