Use of valsartan or its metabolite to inhibit platelet...

A - Human Necessities – 61 – K

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A61K 31/41 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2482541

The invention relates to a method of inhibiting platelet aggregation comprising administering a therapeutically effective amount of an ARB or its metabolite, especially Valsartan or its metabolite valeryl 4-hydroxy valsartan. Conditions to be treated by inhibition of platelet aggregation include acute myocardial infarction, ischemic stroke, angina pectoris, acute coronary syndromes, TIA (transient ischemic attacks, or acute cerebrovascular syndromes), heart failure, chest pain of ischemic etiology, syndrome X, thromboembolism, pulmonary hypertension, diabetes mellitus, peripheral vascular disease, deep vein thrombosis, arterial thrombosis of any vessel, catheter thrombotic occlusion or reocclusion.

L'invention concerne un procédé visant à inhiber l'agrégation plaquettaire, qui comprend l'administration d'une quantité thérapeutiquement efficace d'un ARB ou de son métabolite, notamment le Valsartan ou son métabolite le valéryl 4-hydroxy valsartan. Les affections pouvant être traitées par une inhibition de l'agrégation plaquettaire comprennent l'infarctus aigu du myocarde, l'accident ischémique cérébral, l'angine de poitrine, les syndromes coronaires aigus, les accidents ischémiques transitoires (TIA) ou les syndromes cérébrovasculaires aigus, l'insuffisance cardiaque, la douleur thoracique d'étiologie ischémique, le syndrome X, les maladies thrombo-emboliques, l'hypertension pulmonaire, le diabète sucré, l'acrosyndrome, la thrombose veineuse profonde, la thrombose artérielle d'un vaisseau quelconque, l'occlusion ou la réocclusion thrombotique d'un cathéter.

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