A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61P 3/04 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2752845
The present invention concerns Vgll3 a new target involved in adipogenesis modulation. Further, the present in-vention relates to methods to increase Vgll3 activity in adipocytes and preadipocytes. In addition, pharmaceutical composition comprising Vgll3 activity enhancing molecules in order to enhance the Vgll3 activity in a target tissue are also provided. These methods, compositions and molecules can be useful to modulate adipogenesis and thus treat obesity and related disorders.
La présente invention concerne Vgll3, une nouvelle cible impliquée dans la modulation de l'adipogenèse. En outre, la présente invention a pour objet des méthodes permettant d'augmenter l'activité de Vg113 dans les adipocytes et les préadipocytes. En outre, l'invention concerne également des compositions pharmaceutiques contenant des molécules amplifiant l'activité de Vgll3 afin d'amplifier l'activité de Vgll3 dans un tissu cible. Ces méthodes, compositions et molécules peuvent être utiles pour moduler l'adipogenèse et ainsi traiter l'obésité et des troubles associés.
Hall Diana
Jimenez Maria
Poussin Carine
Thorens Bernard
Robic
Sanofi
LandOfFree
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