Use of vinpocetine derivatives for inhibiting production or...

Details Use of vinpocetine derivatives for inhibiting production or... Use of vinpocetine derivatives for inhibiting production or...

A - Human Necessities

61

K

A61K 31/475 (2006.01)

Patent

CA 2213094

A pharmaceutical composition for inhibiting production or secretion of amyloid .beta. protein, which comprises a compound of formula (I), wherein ring A is an optionally substituted benzene ring, R represents OR1, (a) or SR1, wherein R1, R2 and R3 are the same or different and each is selected from a hydrogen atom, an optionally substituted hydrocarbon group or R2 and R3, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen- containing heterocyclic group, and Y is an optionally substituted alkyl group, or a pharmaceutically acceptable salt thereof, if necessary, with a pharmaceutically acceptable excipient, carrier or diluent.

Composition pharmaceutique visant à inhiber la production ou la secrétion de la protéine amyloïde .beta., qui comprend un composé de la formule (I), où le noyau A est un noyau benzène à substitution optionnelle, R correspond à OR?1¿, (a) ou SR?1¿, R?1¿, R?2¿ et R?3¿ étant identiques ou différents, et constitués, soit d'un atome d'hydrogène, soit d'un groupe hydrocarbure, soit de façon que R?2¿ et R?3¿, combinés avec l'atome d'azote adjacent, forment un groupe hétérocyclique à substitution optionnelle comprenant l'élément azote, et Y étant un groupe alkyle à substitution optionnelle, ou un sel de celui-ci pharmaceutiquement acceptable, si nécessaire, avec un excipient, véhicule ou diluant pharmaceutiquement acceptable.

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