Use of vinyl alcohol homopolymer and copolymers for...

A - Human Necessities – 61 – K

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A61K 9/22 (2006.01) A61K 9/20 (2006.01) C11D 17/00 (2006.01)

Patent

CA 1322722

27 TITLE USE OF VINYL ALCOHOL HOMOPOLYMER AND COPOLYMERS FOR TABLETING ACTIVE MATERIALS ABSTRACT Method of making tablets for active ingredient delivery by compressing a mixture of active ingredient and granular, high viscosity, fully hydrolyzed polyvinyl alcohol or copolymer of vinyl alcohol with methyl acrylate or methyl methacrylate. By use of a crystalline, heat treated polymer, a tablet providing quick active ingredient release is obtained. by using an amorphous, non-heat treated polymer a tablet providing prolonged active ingredient release is obtained. By using blends of crystalline and amorphous polymers, tablets having a range of active ingredient release characteristics can be obtained. The granular, high viscosity, fully hydrolyzed polymers provide flowability, compressibility and processing versatility advantages over conventional tablet binders.

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