Use of vitamin d receptor activators or vitamin d analogs to...

Details Use of vitamin d receptor activators or vitamin d analogs to... Use of vitamin d receptor activators or vitamin d analogs to...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2575153

Disclosed are pharmaceutical compositions containing Vitamin D receptor activators or Vitamin D analogs to treat, prevent or inhibit vascular disease among other conditions. The pharmaceutical compositions may also include ACE inhibitors or other agents. Also disclosed are methods of reducing PAI-1 expression by administering effective amounts of Vitamin D receptor activators or Vitamin D analogs to a mammal in need thereof. Additionally disclosed are methods of preventing, inhibiting or treating thrombosis in a mammal in need of such prevention, inhibition or treatment comprising administering effective amounts of Vitamin D receptor activators or Vitamin D analogs to the mammal.

L~invention décrit des compositions pharmaceutiques contenant des activateurs du récepteur de la vitamine D ou des analogues de la vitamine D pour traiter, prévenir ou inhiber les maladies cardiovasculaires parmi d~autres maladies. Les compositions pharmaceutiques peuvent également inclure des inhibiteurs d~ACE ou d'autres agents. Sont également décrits des procédés pour réduire l~expression de PAI-1 par l~administration de quantités efficaces d~activateurs du récepteur de la vitamine D ou d~analogues de la vitamine D à un mammifère qui le nécessite. Sont également décrits des procédés pour réduire, inhiber ou traiter la thrombose chez un mammifère qui nécessite une telle prévention, inhibition ou traitement, comprenant l~administration de quantités efficaces d~activateurs du récepteur de la vitamine D ou d~analogues de la vitamine D au mammifère.

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