A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/52 (2006.01)
Patent
CA 2055041
HOE 90/S 041 ABSTRACT OF THE DISCLOSURE A family of compounds effective in inhibiting replica- tion of a human retrovirus is comprised of 7-(oxoalkyl) 1,3- dialkyl xanthines of the formula: Image (I) in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. Another family of effective compounds is comprised of compounds of the formula: Image (II) wherein at least one of R1 and R3 is either a ) a branched hydroxyalkyl group of the formula Image in which R4 stands for an alkyl group with 1 to 3 carbon atoms and n stands for a whole number from 2 to 5, the other R1 or R3 group that may optionally be present stands for a hydrogen atom or an aliphatic hydrocarbon group R5 with up to 6 carbon atoms, whose carbon chain may be interrupted by up to 2 oxygen atoms or may be substituted with a hydroxy or oxo group, or b) an oxoallyl group of the formula Image wherein R6 is C1-C6 and p is 2, 3 or 4, the remaining R1 or R3 being as defined above, and R2 is an alkyl group C1-C4. The inhibition of replication of human retroviruses is indicated in humans infected by human immunodeficiency virus (HIV) or susceptible to HIV infection.
Dezube Bruce J.
Novick William J. Jr.
Pardee Arthur B.
Ruprecht Ruth M.
Bereskin & Parr
Dana-Farber Cancer Institute
Hoechst Marion Roussel Inc.
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