C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/40 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01) C12P 7/22 (2006.01) C12P 7/24 (2006.01) C12P 7/42 (2006.01)
Patent
CA 2454686
The invention relates to a biocatalytic process for the oxidation of substituted monocyclic aromatic compounds to the corresponding carboxylic acids and related compounds. In a preferred embodiment the invention describes a biocatalytic process to produce 4-hydroxymethylbenzoic acid and 3- hydroxymethylbenzoic acid from p-xylene and m-xylene, respectively. 4- hydroxymethylbenzoic acid has been prepared by oxidizing p-xylene with a single recombinant microorganism containing the enzyme xylene monooxygenase.
La présente invention concerne un traitement biocatalytique permettant d'oxyder des composés aromatiques monocycliques substitués donnant les acides carboxyliques correspondants et les composés s'y rapportant. Selon un mode de réalisation préféré, l'invention concerne un traitement biocatalytique devant permettre la production d'acide 4-hydroxyméthylbenzoïque et d'acide 3-hydroxyméthylbenzoïque à partir des p-xylène et m-xylène respectivement. L'acide 4-hydroxyméthylbenzoïque résulte de l'oxydation du p-xylène par un unique micro-organisme de recombinaison contenant l'enzyme mono-oxygénase du xylène.
Bramucci Michael G.
Nagarajan Vasantha
Thomas Stuart M.
Bennett Jones Llp
E.i. Du Pont de Nemours And Company
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