Use of zona pellucida glycoproteins for immunocontraception

A - Human Necessities – 61 – K

Patent

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A61K 39/00 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2137363

A vaccine for the immunocontraception of mammals is described. The vaccine consists of zona pellucida antigens and an adjuvant encapsulated in a liposome delivery system. The liposome delivery system allows for the slow release of antigen resulting in a prolonged immune response. In particular, after a single injection of the vaccine, levels of anti-zona pellucida antibodies were detected for up to 22 months. Thus, the vaccine according to the present invention is effective after a single dose and is therefore very useful in immunocontraceptive protocols.

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