Useful hemi-hydrate form of a cerebral function enhancing agent

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/14 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2117669

The hemi-hydrate form of the cerebral function enhancing agent 1-[[1-[2-(trifluoromethyl)-4- pyrimidinyl]-4-piperidinyl]-methyl-2-pyrrolidinone, or BMY-21502 as it is more commonly designated, is an improved form of drug substance having equivalent biopharmaceutical properties compared to the known anhydrous form but providing cost, safety and ecological advantages in manufacture over the known anhydrous form.

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