C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2755950
The present disclosure provides novel hemi- and mono-salts of 7-[(3R,4R)-3- Hydroxy-4-hydroxymethyl-pyrro- lidin-1-ylmethyl]-3,5-dlhydro-pyrrolo[3,2-d]pyrimidin-4-one (Compound 1) with various organic and inorganic acids. In one em- bodiment, the organic acid is a C4 organic diacids. The present disclosure further provides novel methods for preparing these salts. The novel monohydrates hemisalts of the C4 organic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.
La présente invention concerne de nouveaux hémi- et mono-sels de 7-[(3R,4R)-3-hydroxy-4-hydroxyméthyl-pyrrolidin-1-ylméthyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (composé 1) avec différents acides organiques et inorganiques. Dans un mode de réalisation, l'acide organique est un diacide organique en C4. La présente invention concerne en outre de nouveaux procédés de préparation de ces sels. Les nouveaux hémisels monohydrates des diacides organiques en C4 sont isostructuraux et peuvent être préparés avec différentes propriétés. Des acides multiples peuvent être simultanément utilisés et la proportion d'acides peut varier, offrant la possibilité de choisir les hémisels du composé 1 avec les propriétés souhaitées.
Bartley Gary
Cleary Thomas
Lang John F.
Biocryst Pharmaceuticals Inc.
Fogler Rubinoff Llp
LandOfFree
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