A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) A61P 9/04 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2630200
The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.
La présente invention concerne des procédés de traitement de l'hypertrophie cardiaque, l'insuffisance cardiaque, la cardiomyopathie dilatée ou l'hypertension comprenant l'utilisation des domaines de liaison à HDAC-CaMKII. La présente invention révèle non seulement que la CaMKII se lie à HDAC4 sur un site spécifique, mais aussi que des HDAC4 peuvent se dimériser avec d'autres HDAC. Les deux évènements peuvent conduire à l'exportation de HDAC du noyau au cytoplasme, un évènement associé au développement des cardiopathies. Ainsi les procédés de traitement et les procédés de criblage de la présente invention sont de nouvelles tentatives en vue de prévenir, traiter ou identifier des thérapies pour l'hypertrophie cardiaque, l'insuffisance cardiaque, la cardiomyopathie dilatée ou l'hypertension
Backs Johannes
Harrison Brooke
Huynh Khai
Koch Keith
Mckinsey Tim
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Gilead Sciences Inc.
Myogen Inc.
The Board Of Regents Of The University Of Texas System
LandOfFree
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