Uses for gal4-receptor constructs

Details Uses for gal4-receptor constructs Uses for gal4-receptor constructs

G - Physics

01

N

G01N 33/566 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2182908

In accordance with the present invention, it has been discovered that chimeric receptors comprising at least the ligand binding domain of a member of the steroid/thyroid receptor protein superfamily having incorporated therein the DNA binding domain of the yeast GAL4 protein are capable of forming functional homodimers. Such homodimers are useful, for example, in assays to determine the ligand for an orphan member of the steroid/thyroid superfamily of receptors, for identifying compounds which are selective for a specific steroid/thyroid receptor protein from among a plurality of such receptors which respond to a common ligand, and the like.

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