Uses for human non-autologous mesenchymal stem cells

Details Uses for human non-autologous mesenchymal stem cells Uses for human non-autologous mesenchymal stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/075 (2010.01) A61K 35/28 (2006.01) A61K 35/32 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2323073

Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non- autologous mesenchymal stem cells, including methods and preparations for treating and regenerating connective tissue and enhancing bone marrow engraftment in an individual; and for using genetically engineered allogeneic human mesenchymal stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins in gene therapy for correction of genetic disorders or "rebuilding" proteins important in tissue repair.

L'invention concerne des procédés et des dispositifs utilisant des cellules souches mésenchymateuses non autologues. Ledit procédé consiste à traiter un patient au moyen d'une dose efficace de cellules souches mésenchymateuses non autologues. L'invention concerne notamment des procédés et des préparations de traitement et de régénération des tissus conjonctifs, lesquels procédés et préparations favorisent la greffe de moelle osseuse chez un individu. L'invention concerne aussi des procédés d'utilisation de cellules souches mésenchymateuses humaines allogéniques obtenues par génie génétique, qui sont porteuses de gènes voulus, notamment pour l'expression de protéines physiologiquement et pharmacologiquement actives en thérapie génique en vue de la correction de troubles génétiques ou de la "reconstruction" de protéines importantes pour la réparation tissulaire.

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