Uses of a chemokine receptor for inhibiting hiv-1 infection

Details Uses of a chemokine receptor for inhibiting hiv-1 infection Uses of a chemokine receptor for inhibiting hiv-1 infection

C - Chemistry, Metallurgy

07

K

C07K 14/715 (2006.01) A01K 67/027 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/16 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2257991

This invention provides a polypeptide comprising a fragment of a chemokine receptor capable of inhibiting HIV-1 infection. In an embodiment, the chemokine receptor is C-C CKR-5. In another embodiment, the fragment comprises at least one extracellular domain of the chemokine receptor C-C CKR-5. This invention further provides different uses of the chemokine receptor for inhibiting HIV-1 infection.

L'invention concerne un polypeptide comprenant un fragment d'un récepteur de la chémokine capable d'inhiber l'infection par le VIH-1. Dans un mode de réalisation, le récepteur de la chémokine est C-C CKR-5. Dans un autre mode de réalisation, le fragment comprend au moins un domaine extracellulaire du récepteur de la chémokine C-C CKR-5. Cette invention porte en outre sur différentes utilisations du récepteur de la chémokine dans l'inhibition de l'infection par le VIH-1.

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