Uses of anti-cd40 antibodies

Details Uses of anti-cd40 antibodies Uses of anti-cd40 antibodies

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2705263

This invention relates to new uses of anti-CD40 antibodies in the- treatment of diseases or conditions associated with neoplastic B-cell growth in particular use of anti-CD40 antibodies in combination with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP). The invention is particularly useful for the treatment of patients who have previously been administered (i) CHOP, (ii) the chimeric anti-CD20 monoclonal antibody rituximab, or (iii) combination therapy with CHOP and rituximab.

L'invention concerne de nouvelles utilisations d'anticorps anti-CD40 dans le traitement de maladies ou d'affections associées à la croissance des lymphocytes B néoplasiques, en particulier l'utilisation d'anticorps anti-CD40 combinés à de la cyclophosphamide, de la doxorubicine, de la vincristine et de la prednisone (CHOP). La présente invention est particulièrement utile dans le traitement de patients ayant reçu préalablement une administration : (i) de CHOP, (ii) de rituximab, anticorps monoclonal chimérique anti-CD20 ou (iii) d'un traitement combiné de CHOP et de rituximab.

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