Uses of anti-ctla-4 antibodies

Details Uses of anti-ctla-4 antibodies Uses of anti-ctla-4 antibodies

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2560919

The invention relates to treatment of cancer in a mammal who has undergone stem cell transplantation by administering an effective amount of a human anti- CTLA-4 antibody to the mammal. Stem cell transplantation may be allogeneic or autologous stem cell transplantation and may be preceded by a preparatory treatment such as chemotherapy. The methods of the invention may be combined with additional cancer treatments. Further, the invention relates to treatment of cancer using at least 10 mg/kg of a human anti-CTLA-4 antibody, and, more preferably, about 15-20 mg/kg of antibody.

L'invention concerne le traitement du cancer chez un mammifère soumis à une transplantation de cellules souches par administration d'une quantité efficace d'un anticorps humain anti-CTLA-4 à ce mammifère. La transplantation des cellules souches peut être allogène ou autologue et peut être précédée par un traitement préparatoire, tel qu'une chimiothérapie. Ces procédés peuvent être combinés à des traitements supplémentaires contre le cancer. Elle concerne, de plus, le traitement du cancer au moyen d'au moins 10 mg/kg d'un anticorps humain anti-CTLA-4 et, de préférence, environ 15-20 mg/kg d'anticorps.

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