Uses of chemically-modified cholinesterases for...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/18 (2006.01) A61K 38/46 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) C08G 65/329 (2006.01) C12N 9/96 (2006.01) C12N 11/08 (2006.01)

Patent

CA 2445841

A circulatory long-lived cholinesterase (ChE) protein, such as acetylcholinesterase (AChE) or butyrylcholinesterase (BChE), which is a ChE protein modified with a non-antigenic polymer. The ChE may be AChE, such as native AChE of mammalian origin or of non-mammalian origin, or recombinant AChE. The recombinant AChE may be mutated at one or more amino-acid residues. The BChE may be native BChE of mammalian origin or of non-mammalian origin.

La présente invention concerne une protéine cholinestérase (ChE) à longue durée de vie circulatoire, telle que la protéine acétylcholinestérase (AChE) ou la protéine butylcholinestérase (BChE), qui est une protéine ChE modifiée avec un polymère antigénique. Cette protéine ChE peut être une protéine AchE d'origine mammalienne ou non, ou une protéine AChE de recombinaison. Cette protéine AchE de recombinaison peut être mutée au niveau d'un ou de plusieurs résidus d'amino acide. La protéine BchE peut être une protéine BchE naturelle d'origine mammalienne ou non.

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