Uses of fibroblasts or supernatants from fibroblasts for the...

Details Uses of fibroblasts or supernatants from fibroblasts for the... Uses of fibroblasts or supernatants from fibroblasts for the...

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2347914

Disclosed is a method of inducing a reduced immune response to a transplant in a recipient by treating said recipient with an amount of fibroblasts or a supernatant from a fibroblast culture effective to reduce or inhibit host rejection of the transplant. The fibroblasts or a supernatant from a fibroblast culture can be administered before, at the same time as, or after the transplant. This method is effective in reducing an immune response to a transplant without compromising the immune response to other foreign antigens. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease.

L'invention concerne une méthode d'induction d'une réponse immunitaire réduite à une greffe chez un receveur consistant à traiter ledit receveur avec une dose de fibroblastes ou d'un surnageant tirés d'une culture de fibroblastes efficace pour réduire ou inhiber le rejet du greffon par l'hôte. Les fibroblastes ou un surnageant d'une culture de fibroblastes peuvent être administrés avant, simultanément à ou après la greffe. Cette méthode est efficace pour réduire une réponse immunitaire à une greffe sans compromettre la réponse immunitaire à d'autres antigènes étrangers. L'invention concerne également une méthode d'induction d'une réponse immunitaire réduite contre un hôte par des tissus étrangers, c'est-à-dire, une maladie entre le greffon et l'hôte.

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