Uses of gdnf and gdnf receptor

Details Uses of gdnf and gdnf receptor Uses of gdnf and gdnf receptor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A01K 67/027 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2246768

GDNFR.alpha., GDNFR.alpha. extracellular domain (ECD), GDNFR.alpha. variants, chimeric GDNFRae (e.g., GDNFR.alpha. immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFR.alpha.-ligands, for example GDNF, by providing GDNFR.alpha. to the cell. Also provided are methods for using GDNFR.alpha., GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.

L'invention concerne des GDNFR.alpha. (récepteurs des facteurs neurotrophiques dérivés de cellules gliales .alpha.), le domaine extracellulaire (ECD) des GDFNR.alpha., des variants du GDNFR.alpha., le GDNFR.alpha. chimère (par ex. l'immunoadhésine de GDNFR.alpha.) et des anticorps qui se lient à ces derniers (y compris, des anticorps agonistes et de neutralisation). L'invention traite aussi de différentes utilisations de ces molécules, y compris des procédés permettant de moduler l'activité et la survie des cellules par la réponse des GDNFR.alpha.-ligands, par exemple par le GDNF (facteur neurotrophique dérivé de cellules gliales), en alimentant la cellule en GDNFR.alpha.. L'invention décrit aussi des procédés pour utiliser des GDNFR.alpha., des GDNF ou des agonistes de ces derniers, séparément ou en complexes, pour traiter les maladies rénales.

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