Uses of gpr100 receptor in diabetes and obesity regulation

G - Physics – 01 – N

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G01N 33/556 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2571517

We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a Gpr100 associated disease, in particular diabetes and obesity, the method comprising determining whether a candidate molecule is an agonist or antagonist of Gpr100 polypeptide, in which the Gpr100 polypeptide comprises the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO. 5, or a sequence which is at least 90% identical thereto.

L'invention porte sur un procédé d'identification d'une molécule appropriée au traitement, à la prophylaxie ou au soulagement d'une maladie associée à Gpr100, en particulier le diabète et l'obésité : Le procédé consiste à déterminer si une molécule candidate est un agoniste ou un antagoniste du polypeptide Gpr100, le polypeptide Gpr100 comprenant la séquence d'acides aminés présentée dans le NO ID SEQ. 3 ou NO ID SEQ. 5 ou une séquence qui est au moins 90 % identique à celle-ci.

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