C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 17/06 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2735155
Methods of detecting inflammatory disorders using IL-1isoforms are provided. Methods of treating an inflammatory disorder with an anti-IL-1 antibody are also provided. Methods of treating an inflammatory disorder with an anti-IL-1 antibody and at least one of an anti-IL-22 antibody, an anti-IL-17 antibody, or an anti- TNF.alpha. antibody are also provided.
La présente invention concerne des méthodes permettant de détecter des troubles inflammatoires à laide disoformes de lIL-1. Linvention concerne également des méthodes permettant de traiter un trouble inflammatoire à laide dun anticorps anti-IL-1. Linvention concerne également des méthodes permettant de traiter un trouble inflammatoire avec un anticorps anti-IL-1 et au moins un anticorps parmi un anticorps anti-IL-22, un anticorps anti-IL-17, ou un anticorps anti-TNFa.
Carrier Yijun
Dunussi-Joannopoulos Kyriaki
Ma Hak-Ling
Medley Quintus G.
Torys Llp
Wyeth Llc
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