Uses of kappa-conotoxin pviia

Details Uses of kappa-conotoxin pviia Uses of kappa-conotoxin pviia

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 14/35 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2385047

The invention relates to uses of kappa-conotoxin PVIIA (.kappa.-PVIIA), analogs and derivatives for activating ATP-sensitive K+ channels. The activation of ATP-sensitive K+ channels is useful for opening KATP channels which can be used to treat a wide range of disease and injury states, including cerebral and cardiac ischemia and asthma.

L'invention porte sur des utilisation de la .kappa.-conotoxine PVIIA (.kappa.-PVIIA), de ses analogues et de ses dérivés pour activer les canaux K?+¿ sensibles à l'ATP. L'activation de ces canaux, qui provoque l'ouverture des canaux K¿ATP?, peut servir à traiter une large gamme de maladies et lésions dont les ischémies cérébrales et cardiaques, et l'asthme.

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