C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12P 21/08 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2478082
This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier.This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier.This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.
L'invention concerne une composition renfermant une quantité efficace d'anticorps 8H9 monoclonaux ou d'un dérivé de ceux-ci et un excipient approprié. L'invention concerne une composition pharmaceutique renfermant une quantité efficace d'anticorps 8H9 monoclonaux ou d'un dérivé de ceux-ci et un excipient acceptable sur le plan pharmaceutique. L'invention concerne en outre un anticorps différent de l'anticorps 8H9 monoclonal, renfermant les régions de détermination complémentaires de l'anticorps 8H9 monoclonal ou d'un dérivé de celui-ci et capable de se lier au même antigène que l'anticorps 8H9 monoclonal. L'invention concerne aussi une substance capable d'inhiber de manière compétitive la liaison d'anticorps 8H9 monoclonaux; ainsi un scFv isolé d'anticorps 8H9 monoclonaux ou d'un dérivé de ceux-ci et l'antigène 8H9. L'invention concerne enfin différentes utilisations de l'anticorps 8H9 monoclonal ou de son dérivé.
Macpherson Leslie & Tyerman Llp
Sloan-Kettering Institute For Cancer Research
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