Uses of monoclonal antibody 8h9

Details Uses of monoclonal antibody 8h9 Uses of monoclonal antibody 8h9

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2680111

The present invention discloses monoclonal antibody 8H9 which binds to the 4Ig domain isoform of the human B7-homolog 3, 4Ig-B7H3. The present invention provides a method of improving the prognosis or prolonging the survival of a subject bearing tumor cells, the method comprises administering to the subject a composition comprising an effective amount of an agent capable of binding to an antigen recognized by monoclonal antibody 8H9.

Cette invention se rapporte à l'anticorps monoclonal 8H9 qui se fixe à l'isoforme du domaine 4Ig de l'homologue 3 du B7 humain (4Ig-B7-H3). L'invention concerne également un procédé permettant d'améliorer le pronostic ou de prolonger la survie d'un sujet porteur de cellules tumorales, ledit procédé comprenant l'administration chez le sujet d'une composition comprenant une quantité efficace d'un agent capable de se fixer à un antigène reconnu par l'anticorps monoclonal 8H9.

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