Uses of peptides derived from the cytoplasmic domain of the...

C - Chemistry – Metallurgy – 07 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07K 7/00 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2380428

The invention concerns novel uses of peptides derived from the cytoplasmic domain of the amyloid protein precursor (APP); said peptides are in particular sequences including the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP) (one-letter code), selected in the group consisting of the sequences Y¿1?KQYTSIHHGY¿0? (SEQ ID NO:2), Y¿1?KKQYTSIHHGY¿0? (SEQ ID NO:3) and Y¿1?KKKQYTSIHHGY¿0? (SEQ ID NO:4), wherein Y¿0? is nil or represents V, VV, VVE, VVEV or VVVED and Y¿1? represents an internalisation and addressing peptide, derived from the 3?rd¿ helix of homeodomains and structurally related peptides. The invention also concerns the use of a peptide comprising the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP), for selecting and screening products capable of inhibiting apoptosis.

Nouvelles applications de peptides issus du domaine cytoplasmique du précurseur de la protéine amyloïde (APP); lesdits peptides sont notamment constitués par des séquences incluant le domaine juxtamembranaire du domaine cytoplasmique du précurseur de la protéine amyloïde (APP) (code une lettre), sélectionnées dans le groupe constitué par les séquences Y¿1?KQYTSIHHGY¿0? (SEQ ID NO :2), Y¿1?KKQYTSIHHGY¿0? (SEQ ID NO :3) et Y1KKKQYTSIHHGY¿0? (SEQ ID NO :4), dans lesquelles Y¿0? est nul ou représente V, VV, VVE VVEV ou VVEVD et Y¿1? représente un peptide d'internalisation et d'adressage, issu de la 3ème hélice des homéodomaines et de peptides structurellement apparentés. Utilisation d'un peptide comprenant le domaine juxtamembranaire du domaine cytoplasmique du précurseur de la protéine amyloïde (APP), pour la sélection et le criblage de produits aptes à inhiber l'apoptose.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Uses of peptides derived from the cytoplasmic domain of the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Uses of peptides derived from the cytoplasmic domain of the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Uses of peptides derived from the cytoplasmic domain of the... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1936535

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.