Using allosteric hemoglobin modifiers to decrease oxygen...

Details Using allosteric hemoglobin modifiers to decrease oxygen... Using allosteric hemoglobin modifiers to decrease oxygen...

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A01N 1/02 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/325 (2006.01) A61K 31/40 (2006.01) A61K 35/14 (2006.01) C07C 233/29 (2006.01) C07C 233/73 (2006.01) C07C 235/38 (2006.01) C07C 271/58 (2006.01) C07D 209/48 (2006.01)

Patent

CA 2109575

A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen-affinity in blood during storage end can restore the oxygen affinity of outdated blood.

Une famille de composés s'est révélée utile pour modifier l'équilibre allostérique de l'hémoglobine vers un état de faible affinité d'oxygène. Les composés peuvent agir sur l'hémoglobine du sang entier. De plus les composés peuvent maintenir l'affinité de l'oxygène dans le sang lors de son stockage et peuvent restituer l'affinité d'oxygène de sang périmé.

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