C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2171553
The invention provides a composition of matter, comprised of certain oligonucleotides, which inhibit the expression of .beta./A4 peptide of Alzheimer's disease and Down's Syndrome, and nerve growth factor (NGF) to reverse morphological changes caused in neuronal cells by .beta./A4 peptide. Further, pharmaceutical compositions, kits and methods for treatment of .beta./A4 amyloid-induced morphology as well as an assay for screening candidate antisense oligonulcleotides effective in treatment of deleterius effects that are visited upon cells by .beta./A4 amyloid peptide are described.
Composition composée de certains oligonucléotides qui inhibent l'expression du peptide .beta./A4 de la maladie d'Alzheimer et du syndrome de Down, et de facteur de croissance nerveuse (NGF) pour réparer les modifications morphologiques causées dans les cellules neuronales par le peptide .beta./A4. De plus, des compositions pharmaceutiques, des nécessaires et des méthodes de traitement de la morphologie induite par l'amyloïde .beta./A4, ainsi qu'une analyse destinée à détecter les oligonucléotides candidats, efficaces dans le traitement des effets délétères que le peptide amyloïde .beta./A4 provoque dans les cellules, sont décrits.
Agrawal Sudhir
Majocha Ronald E.
Marotta Charles A.
Hybridon Inc.
Smart & Biggar
The General Hospital Corporation
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