Using heat shock proteins to improve the therapeutic benefit...

A - Human Necessities – 61 – K

Patent

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A61K 38/17 (2006.01) A61K 31/352 (2006.01) A61K 31/395 (2006.01) A61K 31/496 (2006.01) A61K 31/519 (2006.01) A61K 31/675 (2006.01) A61K 31/7048 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2483449

The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an .alpha.- 2-macro globulin (.alpha.2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an .alpha.2M preparation is administered in conjunction with a non-vaccine treatment modality for the treatment of cancer or infectious diseases. In the practice of the invention, a preparation comprising HSPs such as but not limited to, hsp70, hsp90 and gp96 alone or in combination with each other, noncovalently or covalently bound to antigenic molecules or .alpha.2M, noncovalently or covalently bound to antigenic molecules is administered in conjunction with a non-vaccine treatment modality.

La présente invention concerne des méthodes d'amélioration d'un résultat de traitement consistant à administrer une préparation de protéine du choc thermique (HSP) ou une préparation d'.alpha.-2-macroglobuline(.alpha.2M) avec une modalité de traitement non vaccinal. En particulier, une préparation de HSP ou une préparation d'.alpha.2M est administrée conjointement à une modalité de traitement non vaccinal pour le traitement du cancer ou de maladies infectieuses. Dans la pratique de l'invention, une préparation contenant des HSP telles que, de façon non exhaustive, hsp70, hsp90 et gp96 seule ou en association mutuelle, liée de façon non covalente ou covalente à des molécules antigéniques ou .alpha.2M, liée de façon non covalente ou covalente à des molécules antigéniques, est administrée en liaison avec une modalité de traitement non vaccinal.

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