Using lectins for contraception, prophylaxis and therapy

Details Using lectins for contraception, prophylaxis and therapy Using lectins for contraception, prophylaxis and therapy

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61F 6/08 (2006.01) A61F 6/10 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2201508

In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are administered to the vagina prior to sexual intercourse. The lectins immobilize the sperm to render them incapable of fertilization and also bind to the microorganisms to render them non-pathogenic or to the cells to prevent infection by the microorganisms. Lectins can also be administered to treat sexually transmitted vaginal infections. The invention also encompasses a device to be placed in the vault of the vagina which comprises a ring which surrounds the cervix and a membrane spanning the central aperture of the ring to prevent the direct contact of ejaculate with the cervical tissues. The device is impregnated or coated with lectins and releases them into the vaginal environment over a period of time.

De manière à prévenir la conception et/ou le développement de maladies sexuellement transmissibles (MST), on administre dans le vagin, avant un rapport sexuel, une ou plusieurs lectines capable de fixer le sperme et/ou les micro-organismes pathogènes responsables des MST. Les lectines immobilisent le sperme, le privent de sa capacité de fertilisation et se fixent également aux micro-organismes pour les rendre non pathogènes ou aux cellules pour empêcher l'infection par les micro-organismes. On peut également administrer les lectines pour traiter des infections vaginales transmises sexuellement. L'invention concerne également un dispositif destiné à être placé dans le dôme vaginal, comprenant un anneau entourant le col de l'utérus ainsi qu'une membrane recouvrant l'ouverture centrale de l'anneau afin d'empêcher le contact direct de l'éjaculat avec les tissus cervicaux. Ce dispositif est imprégné ou revêtu de lectines qu'il libère dans le vagin pendant une certaine période.

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