Using quaternary ammonium salts for transdermal drug delivery

Details Using quaternary ammonium salts for transdermal drug delivery Using quaternary ammonium salts for transdermal drug delivery

A - Human Necessities

61

K

A61K 31/14 (2006.01) A61F 13/00 (2006.01) A61K 47/18 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2384679

A transdermal drug delivery system is disclosed, which includes a polymer, a drug and an amount of a quaternary ammonium salt that is sufficient to act as a penetration enhancer. The quaternary ammonium salt may also be present in an amount sufficient to act as an irritation reducer. Further, the transdermal drug delivery system may also contain a co-enhancer, which provides a synergistic skin permeation enhancing effect when combined with the quaternary ammonium salt. A method for enhancing the transdermal delivery of a drug is also disclosed.

La présente invention concerne un système d'administration de médicament par voie percutanée, comprenant un polymère, un médicament et une quantité d'un sel d'ammonium quaternaire suffisante afin de favoriser la pénétration. Le sel d'ammonium quaternaire peut aussi être présent en une quantité lui permettant de se comporter comme réducteur d'irritation. Le système d'administration de médicament par voie percutanée peut, en outre, contenir un agent d'accentuation permettant d'obtenir, par synergie, un effet de perméation de peau plus important lorsqu'il est combiné au sel d'ammonium quaternaire. L'invention concerne aussi un procédé permettant d'augmenter l'administration d'un médicament par voie percutanée.

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