C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/10 (2006.01) C07K 16/30 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2682155
HMW-MAA antibody cocktails and their uses in detecting cancer and isolating cancer cells are disclosed. Also disclosed are methods of detecting cancer based on the presence of an HMW-MAA genomic sequence in circulating DNA, as well as the increased expression of the HMW-MAA gene and the reduced methylation of the HMW-MAA gene promoter in tissues and circulating cells.
La présente invention concerne des cocktails d'anticorps d'antigènes associés à un mélanome de poids moléculaire élevé (HMW-MAA) et leurs utilisations dans la détection du cancer et l'isolement des cellules cancéreuses. L'invention concerne également des procédés de détection du cancer basés sur la présence d'une séquence génomique de HMW-MAA dans l'ADN circulant, ainsi que l'augmentation de l'expression du gène des HMW-MAA et la réduction de la méthylation du promoteur du gène des HMW-MAA dans les tissus et les cellules en circulation.
Ferrone Soldano
Goto Yasufumi
Hoon Dave S.b.
Kitago Minoru
Wang Xinhui
John Wayne Cancer Institute
Oyen Wiggs Green & Mutala Llp
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