A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/02 (2006.01) A61K 9/00 (2006.01) A61P 27/02 (2006.01) A61P 27/04 (2006.01)
Patent
CA 2377290
The invention relates to the utilization of a highly fluorinated oligomeric alkan as therapeutic agent in ophthalmology, said alkan having general formula [-R F(CH2)n CR1-CR2-]x, wherein R F is a linear or branched perfluorinated alkyl chain C2F5 to C12F23, R1 and R2 are independently selected from the group consisting of H, CH3, C2H5 und C3H7, n is selected from the numbers 0, 1 and 2 and x is a number between 2 and 6, with a molar mass of at least 750. According to the invention, a pharmacological agent is provided that is used in ophthalmology and that causes little or no damage to the retina even when used over a long period.
L'invention concerne l'utilisation comme agent thérapeutique en ophtalmologie d'un alcane oligomère à haute teneur en fluor de formule générale [-R¿F?(CH¿2?)¿n?CR¿1?-CR¿2?-]¿x?, dans laquelle R¿F? représente une chaîne alkyle linéaire ou ramifiée C¿2?F¿5? à C¿12?F¿23?; R¿1? et R¿2? sont sélectionnés indépendamment l'un de l'autre dans le groupe H, CH¿3?, C¿2?H¿5? et C¿3?H¿7?; n est sélectionné parmi 0, 1 et 2; x est compris entre 2 et 6; ledit alcane présentant une masse molaire d'au moins 750. Cet alcane permet de préparer un produit pharmaceutique utilisé en ophtalmologie, ne provoquant aucune lésion ou provoquant seulement une faible lésion de la rétine, même lorsqu'il est administré de manière prolongée.
Gross Udo
Hoerauf Hans
Kemnitz Erhard
Kobuch Karin
Menz Dirk-Henning
Bausch & Lomb Incorporated
Pharm Pur Gmbh
Riches Mckenzie & Herbert Llp
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