A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01)
Patent
CA 2383172
The present invention relates to the discovery that serum amyloid A (SAA) is a ligand for the FPRL 1 receptor. Disclosed herein, are novel biological tools for the study of SAA/FPRL1 complex assembly and prophylactics, therapeutics, and methods of use of the foregoing, which modulate the association of SAA with FPRL1 and thereby effect responses including, but not limited to, signal transduction, chemotaxis, leukocyte migration, immune system response, amyloidosis, inflammatory response, infection, organ rejection, arthritis, atherosclerosis, and neoplasia.
La présente invention à trait à la découverte énoncent que le sérum amyloïde A (SAA) est un liant pour le récepteur de FPRL1. Ladite invention concerne de nouveaux outils biologiques destinés à l'étude de l'ensemble du complexe de SAA/FPRL1, des prophylactiques, des agents thérapeutiques, et des procédés d'utilisation de ce complexe. Lesdits outils biologiques modulent l'association de SAA avec FPRL1, et produisent également des réponses comprenant notamment la transduction de signal, le chimiotactisme, la migration leucocytaire, les réponses du système immunitaire, l'amyloïdose, les réponses inflammatoires, les infections, le rejet d'organes, l'arthrite, l'artériosclérose, et la néoplasie.
Gao Ji-Liang
Gong Wang-Hua
Murphy Philip M.
Oppenheim Joost J.
Su Shao-Bo
Barrigar Intellectual Property Law
The Government Of The United States Of America
LandOfFree
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