Utilization of inhibitors of the kqt1 channel in order to...

A - Human Necessities – 61 – K

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A61K 31/352 (2006.01) A01N 43/16 (2006.01) A61K 31/18 (2006.01) A61K 31/353 (2006.01) A61K 31/4433 (2006.01) A61K 31/5513 (2006.01) A61P 33/10 (2006.01) A61P 33/14 (2006.01)

Patent

CA 2355300

The invention relates to the utilization of inhibitors of the KQT1 channel in order produce a medicament for treating diseases which are caused by parasitic helminths and ectoparasites. According to the invention, inhibitors of the KQT1 channel depict a novel lethal fundamental constituent for parasitic helminths and ectoparasites. Blockers of the cellular KQT1 channel, said channel occurring in the parasitic helminths and ectoparasites, are therefore used to produce a medicament for treating vertebrates and humans which are afflicted with the parasitic helminths or ectoparasites. These KQT1 blockers are used alone as medicaments or in combination with other medicaments and therapeutic measures. Inhibitors of the KQT1 channel also depict a novel working mechanism for plant pests such as insects, spiders, mollusks and nematoda, and are consequently used in order to produce a plant protective agent.

Utilisation d'inhibiteurs du canal KQT1 pour la préparation d'un médicament destiné à traiter des maladies provoquées par des helminthes et des ectoparasites. Les inhibiteurs du canal KQT1 constituent un nouveau principe actif létal pour les helminthes et les ectoparasites. C'est pourquoi des agents bloquants du canal KQT1 cellulaire présent dans les helminthes et les ectoparasites sont utilisés pour préparer un médicament pour le traitement des mammifères et des êtres humains qui sont infestés par des helminthes ou des ectoparasites. Ces agents bloquants de KQT1 sont utilisés comme médicament, seuls ou en combinaison avec d'autres médicaments et d'autres actes thérapeutiques. Les inhibiteurs du canal KQT1 constituent également un nouveau mécanisme d'action contre des parasites des végétaux tels qu'insectes, arachnides, mollusques et nématodes, et ils sont par conséquent utilisés pour la préparation d'un produit phytosanitaire.

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