Utilization of vinpocetine to avoid complications in...

Details Utilization of vinpocetine to avoid complications in... Utilization of vinpocetine to avoid complications in...

A - Human Necessities

01

N

A01N 43/42 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2544035

The present invention is related with the use of vinpocetine and the derivates developed from its formula that maintains the same effects for the treatment of epilepsy and its complications. Our results show that vinpocetine prevents all the abnormalities of the ABR waves that accompany the epileptic cortical activity observed for the ictal and post-ictal periods in two experimental models of epilepsy in vivo, that vinpocetine also inhibits the marked hearing loss and the characteristic EEG changes induced by two convulsing agents that differ in their mechanisms of action. These findings also indicate that the capacity of vinpocetine as an antiepileptic drug is not accompanied by adverse secondary effects.

La présente invention se rapporte à l'utilisation de la vinpocétine et des dérivés de celle-ci que l'on peut mettre au point et qui présentent les mêmes effets pour le traitement de l'épilepsie et de ses complications. Les résultats obtenus montrent que la vinpocétine inhibe toutes les altérations des ondes de la RATC accompagnant l'activité épileptique corticale pendant les périodes ictales et post-ictales dans deux modèles expérimentaux d'épilepsie in vivo et que la vinpocétine inhibe également la perte marquée de l'ouïe et les changements caractéristiques du EEG induit par deux agents convulsifs différents en termes de mécanisme d'action. Ces découvertes indiquent que la capacité de la vinpocétine comme médicament anti-épileptique n'a pas d'effets secondaires.

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