A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/50 (2006.01) C12N 9/82 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2295980
Described herein are methods for producing recombinant forms of asparaginase derived from Wolinella succinogenes. In addition, methods for covalent modification of proteins, including asparaginases, by acylation are also provided. Certain embodiments provide for epitopic-labeling of the amino terminus of W. succinogenes asparaginase. Additional embodiments concern methods for the therapeutic utilization of the native, homotetrameric form of W. succinogenes asparaginase, as well as the use of epitopically-labeled or non-epitopically-labeled recombinant W. succinogenes asparaginase (or a covalently modified analog thereof) in the therapeutic treatment of malignant and non-malignant hematological disease and other diseases where asparagine depletion or deprivation would be efficacious or which respond to asparagine depletion or deprivation, as well as their potential utilization in the therapeutic treatment of autoimmune diseases such as rheumatoid arthritis, AIDS, and SLE.
On décrit des procédés de production de formes recombinantes d'asparaginase dérivées de Wolinella succinogenes. On décrit aussi des procédés de modification covalente de protéines, y compris des asparaginases, par acylation. Certaines formes de réalisation incluent le marquage épitopique de la terminaison amine de l'asparaginase Wolinella succinogenes. Des formes de réalisation complémentaires concernent des procédés d'utilisation thérapeutique de la forme native, homotétramérique de l'asparaginase Wolinella succinogenes, ainsi que l'utilisation de l'asparaginase Wolinella succinogenes recombinant épitopiquement marqué ou non épitopiquement marqué (ou un analogue dudit asparaginase modifié par covalence) dans le traitement de maladies hématologiques malignes ou bénignes ou d'autres maladies dans lesquelles la déplétion ou la privation de l'asparagine serait efficace, ou qui répondent à la déplétion ou à la privation de l'asparagine. Ces formes de réalisation complémentaires concernent en outre l'utilisation potentielle de ces substances pour le traitement de maladies autoimmunes telles que la polyarthrite rhumatoïde, le SIDA, ou l'ESL.
Children's Hospital Los Angeles
Smart & Biggar
LandOfFree
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