Uv stable transdermal therapeutic plaster

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61K 47/08 (2006.01) A61K 47/12 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2515918

The invention relates to a UV stable transdermal therapeutic system (TTS) consisting of a back layer, at least one matrix containing an active substance and, optionally, a withdrawal film and an UV-radiation absorber. An adhesive layer containing said UV-radiation absorber is arranged between the back layer and the matrix containing an active substance which is distant as much as possible from a surface, a separation layer is arranged between the adhesive layer containing said UV-radiation absorber and the matrix containing an active substance, which is as remote as possible from the surface which is impermeable to the active substance and UV radiation absorber. The inventive transdermal therapeutic system exhibits a high stability and is devoid of inconveniences of existing TTS containing a light-sensitive substance.

L'invention concerne un système thérapeutique transdermique stable aux rayonnements UV (TTS), lequel est composé d'une couche arrière, d'au moins une matrice contenant une matière active et, selon le cas, d'un film à retirer, ainsi que d'un absorbeur de rayonnements UV. Une couche adhésive contenant un absorbeur d'UV est disposée entre la couche arrière et la matrice contenant une matière active éloignée le plus possible de la surface et une couche de séparation est placée entre la couche adhésive contenant un absorbeur de rayonnements UV et la matrice contenant une matière active éloignée le plus possible de la surface, laquelle est imperméable à la matière active et imperméable pour l'absorbeur de rayonnements UV. Ledit système thérapeutique transdermique de l'invention offre une grande stabilité sans les inconvénients des TTS existants contenant une matière active sensible à la lumière.

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