A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/116 (2006.01) A61K 39/106 (2006.01) A61K 39/108 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C12N 1/21 (2006.01) C07K 14/28 (2006.01)
Patent
CA 2684742
Oral immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing Escherichia coli (ETEC) and Vibrio cholerae based on the delivery of recombinant cholera toxin B antigen by attenuated, live bacterial vectors derived from Vibrio cholerae are disclosed. The compositions exhibit dual immunogenicity and retain the ability to colonize gastrointestinal mucosa-associated lymphoid tissues.
L'invention concerne des compositions immunogènes orales conférant une double protection contre des Escherichia coli exprimant la toxine labile (LT) entérotoxinogène (ETEC) et Vibrio cholerae en fonction de la délivrance de l'antigène de toxine B du choléra recombinante par des vecteurs bactériens vivants atténués dérivés de Vibrio cholerae. Les compositions présentent une double immunogénicité et conservent la capacité à coloniser des tissus lymphoïdes associés à la muqueuse gastro-intestinale.
Killeen Kevin P.
Roland Kenneth L.
Thomas Lawrence J.
Celldex Therapeutics Inc.
Smart & Biggar
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